Khurrana made his acting debut in 2012 with Shoojit Sircar's romantic comedy Vicky Donor, co-starring Annu Kapoor and Yami Gautam. It marked the production debut of actor John Abraham, and starred Khuranna in the titular role of a sperm donor. In preparation, he attended acting workshops and interacted with medical professionals.[20] For the film's soundtrack, he sang "Pani Da Rang", which he had written and composed with Rochak Kohli back in 2003.[21] Praising the film's ensemble cast, Sukanya Verma of Rediff.com wrote that Khurrana's "candid disposition and roguish face ensures his street smart drollery works like a breeze".[22] With worldwide earnings of over ?610 million (US$8.6 million) against a budget of ?100 million (US$1.4 million), Vicky Donor emerged as a commercial success.[23] At the Filmfare Awards ceremony, Khurrana was awarded trophies for Best Male Debut and Best Male Playback Singer.[24]
In 2013, Khurrana appeared in Forbes India's Celebrity 100 list, ranking 70th with an estimated annual income of ?25.8 million (US$360,000).[25] He then collaborated with Kunaal Roy Kapur in Rohan Sippy's Nautanki Saala! (2013), a comedy based on the French film Après Vous (2005). Anupama Chopra found Khurrana to be "earnest" in it but felt that his comedic work was overshadowed by that of Roy Kapur.[26] He also recorded two songs for the film's soundtrack.[27] A year later, Khurrana teamed with Yash Raj Films (as part of a three-film deal) in the romantic comedy Bewakoofiyaan (2014), co-starring Sonam Kapoor and Rishi Kapoor, about a young man who has trouble convincing his girlfriend's father to approve of their marriage.[28] Writing for The New York Times, Andy Webster disliked the film's "strained, contrived humor" but commended Khurrana for "holding his own opposite [Rishi] Kapoor".[29] Both Nautanki Saala and Bewakoofiyaan were commercially unsuccessful, as was his next release, Hawaizaada (2015).[30] In it, he played the scientist Shivkar Bapuji Talpade, for which he lost weight and learnt to speak Marathi.[31] In the same year, Khurrana collaborated with his wife, Tahira Kashyap, to write his autobiography Cracking the Code: My Journey to Bollywood